Frontiers in Cardiovascular Medicine (Apr 2023)

Artificial intelligence-estimated biological heart age using a 12-lead electrocardiogram predicts mortality and cardiovascular outcomes

  • Yong-Soo Baek,
  • Yong-Soo Baek,
  • Yong-Soo Baek,
  • Dong-Ho Lee,
  • Yoonsu Jo,
  • Sang-Chul Lee,
  • Sang-Chul Lee,
  • Wonik Choi,
  • Wonik Choi,
  • Dae-Hyeok Kim,
  • Dae-Hyeok Kim

DOI
https://doi.org/10.3389/fcvm.2023.1137892
Journal volume & issue
Vol. 10

Abstract

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BackgroundThere is a paucity of data on artificial intelligence-estimated biological electrocardiography (ECG) heart age (AI ECG-heart age) for predicting cardiovascular outcomes, distinct from the chronological age (CA). We developed a deep learning-based algorithm to estimate the AI ECG-heart age using standard 12-lead ECGs and evaluated whether it predicted mortality and cardiovascular outcomes.MethodsWe trained and validated a deep neural network using the raw ECG digital data from 425,051 12-lead ECGs acquired between January 2006 and December 2021. The network performed a holdout test using a separate set of 97,058 ECGs. The deep neural network was trained to estimate the AI ECG-heart age [mean absolute error, 5.8 ± 3.9 years; R-squared, 0.7 (r = 0.84, p < 0.05)].FindingsIn the Cox proportional hazards models, after adjusting for relevant comorbidity factors, the patients with an AI ECG-heart age of 6 years older than the CA had higher all-cause mortality (hazard ratio (HR) 1.60 [1.42–1.79]) and more major adverse cardiovascular events (MACEs) [HR: 1.91 (1.66–2.21)], whereas those under 6 years had an inverse relationship (HR: 0.82 [0.75–0.91] for all-cause mortality; HR: 0.78 [0.68–0.89] for MACEs). Additionally, the analysis of ECG features showed notable alterations in the PR interval, QRS duration, QT interval and corrected QT Interval (QTc) as the AI ECG-heart age increased.ConclusionBiological heart age estimated by AI had a significant impact on mortality and MACEs, suggesting that the AI ECG-heart age facilitates primary prevention and health care for cardiovascular outcomes.

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