Nature Communications (Oct 2021)
Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion
- Chrystian Junqueira Alves,
- Rafael Dariolli,
- Jonathan Haydak,
- Sangjo Kang,
- Theodore Hannah,
- Robert J. Wiener,
- Stefanie DeFronzo,
- Rut Tejero,
- Gabriele L. Gusella,
- Aarthi Ramakrishnan,
- Rodrigo Alves Dias,
- Alexandre Wojcinski,
- Santosh Kesari,
- Li Shen,
- Eric A. Sobie,
- José Paulo Rodrigues Furtado de Mendonça,
- Evren U. Azeloglu,
- Hongyan Zou,
- Roland H. Friedel
Affiliations
- Chrystian Junqueira Alves
- Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Rafael Dariolli
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Jonathan Haydak
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Sangjo Kang
- Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Theodore Hannah
- Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Robert J. Wiener
- Division of Cardiology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Stefanie DeFronzo
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Rut Tejero
- Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Gabriele L. Gusella
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Aarthi Ramakrishnan
- Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Rodrigo Alves Dias
- Department of Physics, Federal University of Juiz de Fora
- Alexandre Wojcinski
- Pacific Neuroscience Institute and John Wayne Cancer Institute at Providence Saint John’s Health Center
- Santosh Kesari
- Pacific Neuroscience Institute and John Wayne Cancer Institute at Providence Saint John’s Health Center
- Li Shen
- Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Eric A. Sobie
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- José Paulo Rodrigues Furtado de Mendonça
- Department of Physics, Federal University of Juiz de Fora
- Evren U. Azeloglu
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Hongyan Zou
- Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Roland H. Friedel
- Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-021-26296-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 23
Abstract
Biomechanical mechanisms orchestrating stem cell dynamics in development remain unclear. Here the authors show that guidance receptor Plexin-B2 organizes actomyosin contractility, cytoskeletal tension and adhesion during multicellular development of human embryonic stem cells and neuroprogenitor cells.
