Nature Communications (May 2021)
In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche
Abstract
Short term systemic expression of the reprogramming factors Oct-3/4, Sox2, Klf4, c-Myc (OSKM) rejuvenates aging cells and promotes tissue regeneration. Here the authors show that myofiber-specific expression of OSKM accelerates muscle regeneration by reducing secretion of muscle stem cell quiescence promoting Wnt4.