Nature Communications (May 2021)

In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche

  • Chao Wang,
  • Ruben Rabadan Ros,
  • Paloma Martinez-Redondo,
  • Zaijun Ma,
  • Lei Shi,
  • Yuan Xue,
  • Isabel Guillen-Guillen,
  • Ling Huang,
  • Tomoaki Hishida,
  • Hsin-Kai Liao,
  • Estrella Nuñez Delicado,
  • Concepcion Rodriguez Esteban,
  • Pedro Guillen-Garcia,
  • Pradeep Reddy,
  • Juan Carlos Izpisua Belmonte

DOI
https://doi.org/10.1038/s41467-021-23353-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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Short term systemic expression of the reprogramming factors Oct-3/4, Sox2, Klf4, c-Myc (OSKM) rejuvenates aging cells and promotes tissue regeneration. Here the authors show that myofiber-specific expression of OSKM accelerates muscle regeneration by reducing secretion of muscle stem cell quiescence promoting Wnt4.