Estimation of cell response in fractionation radiotherapy using different methods derived from linear quadratic model

Abstract

Background. The aim of this study was to use various theoretical methods derived from the Linear Quadratic (LQ) model to calculate the effects of number of subfractions, time intervals between subfractions, dose per subfraction, and overall fraction time on the cells’ survival. Comparison of the results with experimental outcomes of melanoma and breast adenocarcinoma cells was also performed. Finally, the best matched method with experimental outcomes is introduced as the most accurate method in predicting the cell response.

Keywords

• fractionation radiotherapy
• survival
• dose per fraction
• number of fractions
• linear quadratic model