Nature Communications (Feb 2021)

p53 dynamics vary between tissues and are linked with radiation sensitivity

  • Jacob Stewart-Ornstein,
  • Yoshiko Iwamoto,
  • Miles A. Miller,
  • Mark A. Prytyskach,
  • Stephane Ferretti,
  • Philipp Holzer,
  • Joerg Kallen,
  • Pascal Furet,
  • Ashwini Jambhekar,
  • William C. Forrester,
  • Ralph Weissleder,
  • Galit Lahav

DOI
https://doi.org/10.1038/s41467-021-21145-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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p53 mediates the response to irradiation, however, tissues with similar levels of p53 have different radiation sensitivities. Here, the authors show that the in vivo p53 dynamics varies in these tissues after radiation, and the use of Mdm2 inhibitor to sustain p53 activity enhances radiosensitivity.