The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

Robert Lu; Julienne J. O’Rourke; Alexander P. Sobinoff; Joshua A. M. Allen; Christopher B. Nelson; Christopher G. Tomlinson; Michael Lee; Roger R. Reddel; Andrew J. Deans; Hilda A. Pickett

doi:10.1038/s41467-019-10180-6

Nature Communications (May 2019)

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

Robert Lu,
Julienne J. O’Rourke,
Alexander P. Sobinoff,
Joshua A. M. Allen,
Christopher B. Nelson,
Christopher G. Tomlinson,
Michael Lee,
Roger R. Reddel,
Andrew J. Deans,
Hilda A. Pickett

Affiliations

Robert Lu: Telomere Length Regulation Unit, Children’s Medical Research Institute, Faculty of Medicine and Health, University of Sydney
Julienne J. O’Rourke: Genome Stability Unit, St. Vincent’s Institute
Alexander P. Sobinoff: Telomere Length Regulation Unit, Children’s Medical Research Institute, Faculty of Medicine and Health, University of Sydney
Joshua A. M. Allen: Telomere Length Regulation Unit, Children’s Medical Research Institute, Faculty of Medicine and Health, University of Sydney
Christopher B. Nelson: Telomere Length Regulation Unit, Children’s Medical Research Institute, Faculty of Medicine and Health, University of Sydney
Christopher G. Tomlinson: Telomere Length Regulation Unit, Children’s Medical Research Institute, Faculty of Medicine and Health, University of Sydney
Michael Lee: Telomere Length Regulation Unit, Children’s Medical Research Institute, Faculty of Medicine and Health, University of Sydney
Roger R. Reddel: Cancer Research Unit, Children’s Medical Research Institute, Faculty of Medicine and Health, University of Sydney
Andrew J. Deans: Genome Stability Unit, St. Vincent’s Institute
Hilda A. Pickett: Telomere Length Regulation Unit, Children’s Medical Research Institute, Faculty of Medicine and Health, University of Sydney

DOI: https://doi.org/10.1038/s41467-019-10180-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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ALT telomeres experience DNA damage that may drive recombination-based telomere elongation. Here, the authors reveal that FANCM plays a critical role in the suppression of ALT activity through its interaction with the BTR (BLM-TOP3A-RMI) complex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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