Small RNA mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in Helicobacter pylori

Sandy R. Pernitzsch; Mona Alzheimer; Belinda U. Bremer; Marie Robbe-Saule; Hilde De Reuse; Cynthia M. Sharma

doi:10.1038/s41467-021-24689-2

Nature Communications (Jul 2021)

Small RNA mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in Helicobacter pylori

Sandy R. Pernitzsch,
Mona Alzheimer,
Belinda U. Bremer,
Marie Robbe-Saule,
Hilde De Reuse,
Cynthia M. Sharma

Affiliations

Sandy R. Pernitzsch: Department of Molecular Infection Biology II, Institute of Molecular Infection Biology (IMIB), University of Würzburg
Mona Alzheimer: Department of Molecular Infection Biology II, Institute of Molecular Infection Biology (IMIB), University of Würzburg
Belinda U. Bremer: Department of Molecular Infection Biology II, Institute of Molecular Infection Biology (IMIB), University of Würzburg
Marie Robbe-Saule: Institut Pasteur, Helicobacter Pathogenesis Unit, Microbiology Department
Hilde De Reuse: Institut Pasteur, Helicobacter Pathogenesis Unit, Microbiology Department
Cynthia M. Sharma: Department of Molecular Infection Biology II, Institute of Molecular Infection Biology (IMIB), University of Würzburg

DOI: https://doi.org/10.1038/s41467-021-24689-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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The small RNA RepG modulates expression of chemotaxis receptor TlpB in Helicobacter pylori by targeting a length-variable G-repeat in the tlpB mRNA. Here, Pernitzsch et al. show that RepG also gradually controls lipopolysaccharide biosynthesis, antibiotic susceptibility, and in-vivo colonization of the stomach, by regulating a gene that is co-transcribed with tlpB.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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