Cell Death Discovery (Apr 2024)

MiR-134-5p inhibits the malignant phenotypes of osteosarcoma via ITGB1/MMP2/PI3K/Akt pathway

  • Lei Yan,
  • Ruhao Zhou,
  • Yi Feng,
  • Ruoqi Li,
  • Long Zhang,
  • Yongchun Pan,
  • Xiaochen Qiao,
  • Pengcui Li,
  • Xiaochun Wei,
  • Chaojian Xu,
  • Yuan Li,
  • Xiaochen Niu,
  • Xiaojuan Sun,
  • Zhi Lv,
  • Zhi Tian

DOI
https://doi.org/10.1038/s41420-024-01946-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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Abstract Micro RNAs (miRs) have been implicated in various tumorigenic processes. Osteosarcoma (OS) is a primary bone malignancy seen in adolescents. However, the mechanism of miRs in OS has not been fully demonstrated yet. Here, miR-134-5p was found to inhibit OS progression and was also expressed at significantly lower levels in OS tissues and cells relative to normal controls. miR-134-5p was found to reduce vasculogenic mimicry, proliferation, invasion, and migration of OS cells, with miR-134-5p knockdown having the opposite effects. Mechanistically, miR-134-5p inhibited expression of the ITGB1/MMP2/PI3K/Akt axis, thus reducing the malignant features of OS cells. In summary, miR-134-5p reduced OS tumorigenesis by modulation of the ITGB1/MMP2/PI3K/Akt axis, suggesting the potential for using miR-134-5p as a target for treating OS.