Zhongguo linchuang yanjiu (Jun 2023)
Detection value of six serum indicators in non-small cell lung cancer patients
Abstract
Objective To explore the changes and clinical significance of serum levels of Galectin-3, high mobility group protein A2 (HMGA2) , neuropilin-1 (NRP-1) , carcino-embryonic antigen (CEA) , squamous cell carcinoma antigen (SCC-AG) and cytokeratin-19 fragment (CYFRA 21-1) in patients with non-small cell lung cancer (NSCLC) . Methods A retrospective study was conclucted on 79 patients with NSCLC (NSCLC group) , 39 patients with benign lung diseases (benign control group) and 50 healthy examinees (healthy control group) treated or examined in Chuzhou First People's Hospital from March 2019 to March 2022. The serum levels of Galectin-3, HMGA2, NRP-1, CEA, SCC-Ag and CYFRA 21-1 were compared among three groups to analyze the associations of Galectin-3, HMGA2 and NRP-1 with clinicopathological characteristics of NSCLC and their predictive value on lymph node metastasis and clinical staging of NSCLC. Results The serum levels of Galectin-3, HMGA2, NRP-1, CEA, SCC-Ag and CYFRA 21-1 in NSCLC group were significantly higher than those in benign control group and healthy control group (P＜0.05) . The serum levels of Galectin-3, HMGA2, NRP-1, CEA and CYFRA 21-1 were all or partially correlated with tumor diameter, differentiation, lymph node metastasis and clinical stage in NSCLC patients (P<0.05) , and SCC-Ag level was related to pathological type (P<0.05) . Multivariate logistic regression analysis showed that Galectin-3, HMGA2, NRP-1, CEA and CYFRA 21-1 were the independent risk factors influencing lymph node metastasis and clinical stage Ⅲ-Ⅳ of NSCLC (P＜0.05) . The AUCs of serum Galectin-3, HMGA2, NRP-1, CEA and CYFRA 21-1 in predicting lymph node metastasis in NSCLC were 0.950, 0.878, 0.745, 0.771 and 0.706, respectively, and the AUCs in predicting clinical stage Ⅲ-Ⅳ were 0.934, 0.865, 0.755, 0.695 and 0.698, respectively. Conclusion In the patients with NSCLC, the serum levels of Galectin-3, HMGA2, NRP-1, CEA, SCC-Ag and CYFRA 21-1 are significantly increased, and Galectin-3, HMGA2 and NRP-1 are related to lymph node metastasis and clinical staging. They can be used as new predictive indicators of lymph node metastasis and clinical staging of NSCLC.
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