SNHG20 promotes the development of laryngeal squamous cell carcinoma via miR-342-3p/MTDH axis
Zuozhong Xie,
Hong Xiang,
Jingkun Li,
Xiaowei Zhang,
Wei Li,
Guolin Tan
Affiliations
Zuozhong Xie
Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital, Central South University, Changsha City, Hunan Province, 410013, China
Hong Xiang
Center for Experimental Medical Research, The Third Xiangya Hospital, Central South University, Changsha City, Hunan Province, 410013, China
Jingkun Li
Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha City, Hunan Province, 410013, China
Xiaowei Zhang
Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital, Central South University, Changsha City, Hunan Province, 410013, China
Wei Li
Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital, Central South University, Changsha City, Hunan Province, 410013, China
Guolin Tan
Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital, Central South University, Changsha City, Hunan Province, 410013, China; Corresponding author.
Long noncoding RNAs (lncRNAs) are important players in laryngeal squamous cell carcinoma (LSCC). However, the function of the long noncoding RNA small nucleolar RNA host gene 20 (SNHG20) in LSCC is hardly known. We therefore analyzed the role of this lncRNA in LSCC. Our data showed that SNHG20 was significantly overexpressed in LSCC cell lines and human LSCC tissue. SNHG20 significantly promoted cell proliferation, migration and invasion of LSCC cells. The actions of SNHG20 are likely mediated by miR-342-3p expression, which results in increased expression of MTDH. Finally, the results of in vivo models confirmed that SNHG20 promotes LSCC progression through modulating miR-342-3p and MTDH expression. Taken together, our study demonstrates that SNHG20/miR-342-3p/MTDH axis participates in LSCC progression.
