Preparation of silymarin nanocrystals using a novel high pressure crystallization technique and evaluation of its dissolution and absorption properties

• Risako Onodera,
• Tomohiro Hayashi,
• Tatsuo Nakamura,
• Kaori Aibe,
• Kohei Tahara,
• Hirofumi Takeuchi

Affiliations

Risako Onodera

Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan

Tomohiro Hayashi

Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan

Tatsuo Nakamura

FANCL Corporation, 12-13 Kamisinano Totsuka-ku, Yokohama, Kanagawa 244-0806, Japan

Kaori Aibe

FANCL Corporation, 12-13 Kamisinano Totsuka-ku, Yokohama, Kanagawa 244-0806, Japan

Kohei Tahara

Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan

Hirofumi Takeuchi

Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan