Mononuclear and Dinuclear Copper(II) Complexes Containing N, O and S Donor Ligands: Synthesis, Characterization, Crystal Structure Determination and Antimicrobial Activity of [Cu(phen)(tda)].2H2O and [(phen)2Cu(µ-tda)Cu(phen)](ClO4)2.1.5H2O

Abstract

Copper complexes of [Cu(phen)(tda)].2H2O(1) and [(phen)2Cu(µ-tda) Cu(phen)](ClO4)2.1.5H2O (2) (where phen is 1,10-phenanthroline and tda2- is thiodiacetate) have been synthesized. Both complexes were characterized by elemental analysis, IR, UV–Vis spectroscopy and cyclic voltammetry. Their solid state structures were determined by the single crystal X-Ray Diffraction method. Complex 1 is mononuclear and copper has accepted a five-coordinated square-based pyramidal structure with the tda2- anion facially coordinated to copper(II). Complex 2 has accepted an unsymmetrical square pyramidal coordination of two distinct copper complexes, one containing two phenanthroline and the other containing one phenanthroline and one tda2-, bridged by a carboxylate oxygen. The strong biological activity of these compounds against six reference bacterial included Bacillus subtilis (ATCC 465), Enterococcus faecalis (ATCC 29737), Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 10031), and Pseudomonas aeruginosa (ATCC 85327) were investigated.

Keywords

• cu(ii) complexes
• 1
• 10-phenanthroline
• thiodiacetic acid
• crystal structure
• cyclic voltammogram. antimicrobial activities