Porous microneedle-based wearable device for monitoring of transepidermal potential

Yuina Abe; Ryohei Takizawa; Natsumi Kimura; Hajime Konno; Shotaro Yoshida; Matsuhiko Nishizawa

Biomedical Engineering Advances (Jun 2021)

Porous microneedle-based wearable device for monitoring of transepidermal potential

Yuina Abe,
Ryohei Takizawa,
Natsumi Kimura,
Hajime Konno,
Shotaro Yoshida,
Matsuhiko Nishizawa

Affiliations

Yuina Abe: Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki-aza Aoba, Aoba-ku, Sendai 980-8579, Japan
Ryohei Takizawa: Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki-aza Aoba, Aoba-ku, Sendai 980-8579, Japan
Natsumi Kimura: Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki-aza Aoba, Aoba-ku, Sendai 980-8579, Japan
Hajime Konno: Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki-aza Aoba, Aoba-ku, Sendai 980-8579, Japan
Shotaro Yoshida: Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki-aza Aoba, Aoba-ku, Sendai 980-8579, Japan
Matsuhiko Nishizawa: Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki-aza Aoba, Aoba-ku, Sendai 980-8579, Japan; Division for the Establishment of Frontier Sciences of the Organization for Advanced Studies, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan; Corresponding author at: Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki-aza Aoba, Aoba-ku, Sendai 980-8579, Japan.

Journal volume & issue: Vol. 1
p. 100004

Abstract

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Transepidermal potential (TEP), an electrical potential difference of tens of millivolts that is generated along the thickness direction of the epidermis, is a possible indicator of epidermal function, including the permeability barrier of skin. Herein, a patch-type wearable device for minimally invasive monitoring of TEP was developed by utilizing a porous microneedle (PMN) array made of an epoxy resin. In order to measure the potential of the subepidermal tissue, the entire surface of the PMN except for the needle tip was coated by a thin film of insulating parylene C. The open-tip PMN was integrated with a wearable potentiometric device composed of a pair of screen-printed Ag/AgCl electrodes. By optimizing the porosity and the size of the liquid junction, the TEP of tens of mV at a subject's forearm was successfully monitored over a 4 h period.

Published in Biomedical Engineering Advances

ISSN: 2667-0992 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical technology
Website: https://www.journals.elsevier.com/biomedical-engineering-advances

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