OSOBENNOSTI STRUKTURNOY ORGANIZATsIISUSTAVNOGO KhRYaShchA v zavisimosti ot stadii gonartroza

Abstract

The purpose - revealing of features of the structural organization of the articulate cartilage of a knee joint at patients with various stages of arthrosis. Materials and methods. Morphological researches of an articulate cartilage are visited at 52 patients with various stages of gonarthrosis. The control group was made by 5 men and 5 women in the age of from 18 till 25 years with traumatic damages of components of a knee joint. The basic group was made by 42 persons. On a stage of gonarthrosis patients have been divided into 2 subgroups: 23 patients with 1-2 stage and 19 patients with 2-3 stage of gonarthrosis. The histological material for research has been received at performance medical-diagnostic arthroscopies a knee joint. Results. It is noted, that morphological changes in an articulate cartilage at gonarthrosis are connected with change of density intercellular matrix and, depending on a stage of process, of chondrocyte dystrophy, necrosis and apoptosis are took place. In cytoplasm of chondrocyte there is a decrease in concentration of cytoplasmic organelles, lipids accumulation and electron density inclusions. Conclusion. The most expressed structural changes in the articulate cartilage, connected with local destruction of chondrocytes, lipids and electron density inclusions accumulation are noted at patients with 2-3 stage of gonarthrosis.