Communications Biology (Apr 2023)
PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing
- Eulashini Chuntharpursat-Bon,
- Oleksandr V. Povstyan,
- Melanie J. Ludlow,
- David J. Carrier,
- Marjolaine Debant,
- Jian Shi,
- Hannah J. Gaunt,
- Claudia C. Bauer,
- Alistair Curd,
- T. Simon Futers,
- Paul D. Baxter,
- Michelle Peckham,
- Stephen P. Muench,
- Antony Adamson,
- Neil Humphreys,
- Sarka Tumova,
- Robin S. Bon,
- Richard Cubbon,
- Laeticia Lichtenstein,
- David J. Beech
Affiliations
- Eulashini Chuntharpursat-Bon
- School of Medicine, University of Leeds
- Oleksandr V. Povstyan
- School of Medicine, University of Leeds
- Melanie J. Ludlow
- School of Medicine, University of Leeds
- David J. Carrier
- School of Medicine, University of Leeds
- Marjolaine Debant
- School of Medicine, University of Leeds
- Jian Shi
- School of Medicine, University of Leeds
- Hannah J. Gaunt
- School of Medicine, University of Leeds
- Claudia C. Bauer
- School of Medicine, University of Leeds
- Alistair Curd
- School of Molecular and Cellular Biology, University of Leeds
- T. Simon Futers
- School of Medicine, University of Leeds
- Paul D. Baxter
- School of Medicine, University of Leeds
- Michelle Peckham
- School of Molecular and Cellular Biology, University of Leeds
- Stephen P. Muench
- School of Biomedical Sciences, University of Leeds
- Antony Adamson
- Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building
- Neil Humphreys
- Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building
- Sarka Tumova
- School of Medicine, University of Leeds
- Robin S. Bon
- School of Medicine, University of Leeds
- Richard Cubbon
- School of Medicine, University of Leeds
- Laeticia Lichtenstein
- School of Medicine, University of Leeds
- David J. Beech
- School of Medicine, University of Leeds
- DOI
- https://doi.org/10.1038/s42003-023-04706-4
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 18
Abstract
The PIEZO1 channel and the PECAM1 cell adhesion molecule interact and PIEZO1 cooperates with PECAM1 and CDH5 cell junctions during mechanical stress.
