Integrated indices as a criterion for evaluation of the level of endogenous intoxication for leptospirosis in dogs
Abstract
One of the most important directions in the development of modern veterinary medicine is the improvement and implementation of modern methods of diagnosis and prognosis of diseases based on determining the degree of dysfunction and the possibility of correcting the protective functions of the body. for most veterinary clinics, the study of the immunological status of animals is not available, and clinical blood tests make it possible to determine the assessment of the functional state of the immune system by integrated hematological parameters. In the article on the basis of blood formulas that reflect the state of neurohumoral homeostasis and immunological reactivity of the organism, for the first time investigated and established violations of humoral and cellular immune systems, micro- and macrophage systems, reduced nonspecific protection and found relationships between immunity in 23 dogs with leptospirosis, which calculated 19 markers of inflammatory activity, endogenous intoxication, adaptation, nonspecific and immune reactivity. The study was conducted in veterinary clinics in zhytomyr and kyiv, blood for the study was taken from the superficial vein of the forearm v. anterbrachium, medial subcutaneous vein or subcutaneous tibial vein v. saphena. Diagnostic studies to confirm leptospirosis were performed using rapid tests Combo Test IgG Ab/IgM Ab, vetlaboratories and elisa on the basis of a private veterinary laboratory of Llc “Bald” in Kiev. The interpretation of integrated leukocyte blood parameters revealed the development of autoimmune processes with suppression of cellular immunity and the development of endogenous intoxication, which indicates an increase in total (P < 0.01), leukocyte (P < 0.05) and nuclear index (P< 0.001). Suppression of the immune response and increased hypersensitivity of the immediate type based on a decrease in non-specific reactivity by P < 0.001 and inflammation index by P < 0.05. It is proved that integrated hematological parameters of peripheral blood increase the informativeness of the general analysis of blood in dogs with infectious diseases and allow to determine not only the degree of reactivity of the organism, but also to assess the level of endogenous intoxication.
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