Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

Jesus Cosin-Roger; Simona Simmen; Hassan Melhem; Kirstin Atrott; Isabelle Frey-Wagner; Martin Hausmann; Cheryl de Vallière; Marianne R. Spalinger; Patrick Spielmann; Roland H. Wenger; Jonas Zeitz; Stephan R. Vavricka; Gerhard Rogler; Pedro A. Ruiz

doi:10.1038/s41467-017-00213-3

Nature Communications (Jul 2017)

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

Jesus Cosin-Roger,
Simona Simmen,
Hassan Melhem,
Kirstin Atrott,
Isabelle Frey-Wagner,
Martin Hausmann,
Cheryl de Vallière,
Marianne R. Spalinger,
Patrick Spielmann,
Roland H. Wenger,
Jonas Zeitz,
Stephan R. Vavricka,
Gerhard Rogler,
Pedro A. Ruiz

Affiliations

Jesus Cosin-Roger: Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich
Simona Simmen: Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich
Hassan Melhem: Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich
Kirstin Atrott: Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich
Isabelle Frey-Wagner: Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich
Martin Hausmann: Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich
Cheryl de Vallière: Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich
Marianne R. Spalinger: Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich
Patrick Spielmann: Institute of Physiology, University of Zurich
Roland H. Wenger: Institute of Physiology, University of Zurich
Jonas Zeitz: Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich
Stephan R. Vavricka: Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich
Gerhard Rogler: Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich
Pedro A. Ruiz: Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich

DOI: https://doi.org/10.1038/s41467-017-00213-3
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

Hypoxia and HIF-1α activation are protective in mouse models of colitis, and the latter regulates autophagy. Here Cosin-Roger et al. show that hypoxia ameliorates intestinal inflammation in Crohn’s patients and murine colitis models by inhibiting mTOR/NLRP3 pathway and promoting autophagy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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