Nature Communications (Aug 2019)
Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation
- Jemma Victoria Walker,
- Heng Zhuang,
- Donald Singer,
- Charlotte Sara Illsley,
- Wai Ling Kok,
- Kishor K. Sivaraj,
- Yan Gao,
- Chloe Bolton,
- Yuying Liu,
- Mengyuan Zhao,
- Portia Rebecca Clare Grayson,
- Shuang Wang,
- Jana Karbanová,
- Tim Lee,
- Stefano Ardu,
- Qingguo Lai,
- Jihui Liu,
- Moustapha Kassem,
- Shuo Chen,
- Kai Yang,
- Yuxing Bai,
- Christopher Tredwin,
- Alexander C. Zambon,
- Denis Corbeil,
- Ralf Adams,
- Basem M. Abdallah,
- Bing Hu
Affiliations
- Jemma Victoria Walker
- Stem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of Plymouth
- Heng Zhuang
- Department of Cariology, Endodontology and Operative Dentistry, Peking University School and Hospital of Stomatology
- Donald Singer
- Stem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of Plymouth
- Charlotte Sara Illsley
- Stem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of Plymouth
- Wai Ling Kok
- Stem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of Plymouth
- Kishor K. Sivaraj
- Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine
- Yan Gao
- Stem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of Plymouth
- Chloe Bolton
- Stem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of Plymouth
- Yuying Liu
- Stem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of Plymouth
- Mengyuan Zhao
- Institute of Dental Research, Beijing Stomatological Hospital, Capital Medical University
- Portia Rebecca Clare Grayson
- Stem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of Plymouth
- Shuang Wang
- Faculty of Dentistry, National University of Singapore
- Jana Karbanová
- Tissue Engineering Laboratories (BIOTEC), Technische Universität Dresden
- Tim Lee
- Department of Biopharmaceutical Sciences, Keck Graduate Institute
- Stefano Ardu
- Clinique Universitaire de Médecine Dentaire, Université de Genève
- Qingguo Lai
- Department of Oral and Maxillofacial Surgery, the Second Hospital of Shandong University
- Jihui Liu
- Department of Orthodontics, Shenyang Stomatological Hospital
- Moustapha Kassem
- Molecular Endocrinology Lab (KMEB), Department of Endocrinology, Odense University Hospital & University of Southern Denmark
- Shuo Chen
- Department of Developmental Dentistry, Dental School, The University of Texas Health Science Center at San Antonio
- Kai Yang
- Department of Orthodontics, School of Stomatology, Capital Medical University
- Yuxing Bai
- Department of Orthodontics, School of Stomatology, Capital Medical University
- Christopher Tredwin
- Stem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of Plymouth
- Alexander C. Zambon
- Department of Biopharmaceutical Sciences, Keck Graduate Institute
- Denis Corbeil
- Tissue Engineering Laboratories (BIOTEC), Technische Universität Dresden
- Ralf Adams
- Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine
- Basem M. Abdallah
- Molecular Endocrinology Lab (KMEB), Department of Endocrinology, Odense University Hospital & University of Southern Denmark
- Bing Hu
- Stem Cells & Regenerative Medicine Laboratory, Peninsula Dental School, University of Plymouth
- DOI
- https://doi.org/10.1038/s41467-019-11611-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Mouse incisor growth depends upon mesenchymal stromal cells (MSCs) and transit amplifying cells (TACs). Here the authors describe a distinct population of MSCs that is maintained by TACs through Dlk1 ligand and that contribute to MTACs and mesenchymal lineages including dental pulp and odontoblasts.
