The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition

Rakesh Ganji; Joao A. Paulo; Yuecheng Xi; Ian Kline; Jiang Zhu; Christoph S. Clemen; Conrad C. Weihl; John G. Purdy; Steve P. Gygi; Malavika Raman

doi:10.1038/s41467-023-36298-2

Nature Communications (Feb 2023)

The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition

Rakesh Ganji,
Joao A. Paulo,
Yuecheng Xi,
Ian Kline,
Jiang Zhu,
Christoph S. Clemen,
Conrad C. Weihl,
John G. Purdy,
Steve P. Gygi,
Malavika Raman

Affiliations

Rakesh Ganji: Department of Developmental Molecular and Chemical Biology, Tufts University School of Medicine
Joao A. Paulo: Department of Cell Biology, Harvard Medical School
Yuecheng Xi: Department of Immunobiology, BIO5 Institute, University of Arizona College of Medicine
Ian Kline: Department of Immunobiology, BIO5 Institute, University of Arizona College of Medicine
Jiang Zhu: Department of Neurology, Washington University School of Medicine
Christoph S. Clemen: Institute of Aerospace Medicine, German Aerospace Center
Conrad C. Weihl: Department of Neurology, Washington University School of Medicine
John G. Purdy: Department of Immunobiology, BIO5 Institute, University of Arizona College of Medicine
Steve P. Gygi: Department of Cell Biology, Harvard Medical School
Malavika Raman: Department of Developmental Molecular and Chemical Biology, Tufts University School of Medicine

DOI: https://doi.org/10.1038/s41467-023-36298-2
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 20

Abstract

Read online

Inter-organellar contacts are hubs for several critical cellular processes, such as lipid synthesis. Here Ganji et al. show that the p97-UBXD8 complex modulates contacts by regulating membrane lipid composition and saturation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal