Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection

Sang-Cuo Nao; Ke-Jia Wu; Wanhe Wang; Chung-Hang Leung; Dik-Lung Ma

doi:10.3389/fchem.2020.00767

Frontiers in Chemistry (Sep 2020)

Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection

Sang-Cuo Nao,
Ke-Jia Wu,
Wanhe Wang,
Chung-Hang Leung,
Dik-Lung Ma

Affiliations

Sang-Cuo Nao: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, China
Ke-Jia Wu: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, China
Wanhe Wang: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, China
Chung-Hang Leung: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, China
Dik-Lung Ma: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, China

DOI: https://doi.org/10.3389/fchem.2020.00767
Journal volume & issue: Vol. 8

Abstract

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Ochratoxin A (OTA) is a mycotoxin that is widespread throughout the world. It contaminates foods such as vegetables, fruits, and rice. It harms human health and has potential carcinogenic effects. The G-quadruplex (G4) is a tetraplexed DNA structure generated from guanine-rich DNA that has found emerging use in aptamer-based sensing systems. This review outlines the status of OTA contamination and conventional detection methods for OTA. Various G4-based methods to detect OTA developed in recent years are summarized along with their advantages and disadvantages compared to existing approaches.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

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