Datasets describing the growth and molecular features of hepatocellular carcinoma patient-derived xenograft cells grown in a three-dimensional macroporous hydrogel
Eliza Li Shan Fong,
Tan Boon Toh,
Quy Xiao Xuan Lin,
Zheng Liu,
Lissa Hooi,
Masturah Bte Mohd Abdul Rashid,
Touati Benoukraf,
Edward Kai-Hua Chow,
The Hung Huynh,
Hanry Yu
Affiliations
Eliza Li Shan Fong
Department of Biomedical Engineering, National University of Singapore, Singapore; Corresponding authors.
Tan Boon Toh
Cancer Science Institute of Singapore, National University of Singapore, Singapore
Quy Xiao Xuan Lin
Cancer Science Institute of Singapore, National University of Singapore, Singapore
Zheng Liu
Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research (A⁎STAR) Singapore
Lissa Hooi
Cancer Science Institute of Singapore, National University of Singapore, Singapore
Masturah Bte Mohd Abdul Rashid
Cancer Science Institute of Singapore, National University of Singapore, Singapore
Touati Benoukraf
Cancer Science Institute of Singapore, National University of Singapore, Singapore
Edward Kai-Hua Chow
Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Corresponding author at: Cancer Science Institute, National University of Singapore, Singapore.
The Hung Huynh
National Cancer Center Singapore, Singapore; Corresponding authors.
Hanry Yu
Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research (A⁎STAR) Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Mechanobiology Institute, National University of Singapore, Singapore; BioSyM, Singapore-MIT Alliance for Research and Technology, Singapore; Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China; NUS Graduate School of Integrative Sciences and Engineering, National University of Singapore, Singapore
This data article presents datasets associated with the research article entitled “Generation of matched patient-derived xenograft in vitro–in vivo models using 3D macroporous hydrogels for the study of liver cancer” (Fong et al., 2018) [1]. A three-dimensional macroporous sponge system was used to generate in vitro counterparts to various hepatocellular carcinoma patient-derived xenograft (HCC-PDX) lines. This article describes the viability, proliferative capacity and molecular features (genomic and transcriptomic profiles) of the cultured HCC-PDX cells. The sequencing datasets are made publicly available to enable critical or further analyzes.
