Research progress on biodosimeters of ionizing radiation damage

Abstract

Ionizing radiation can cause radiation injury to the human body under certain circumstances, such as unexpected radiation accidents and nuclear terrorist attacks. Methods that can accurately and rapidly measure the biological effects are necessary for rational triage and treatment of affected patients. In recent decades, significant researches attention has been focused on the development of accurate and efficient biodosimeters. In this review, we summarize recent developments in biological dosimeters, with a primary focus on cell-based and molecular markers, including comet assay, dicentric chromosome aberration, γ-H2AX, micronuclei, microRNA, lncRNA, and 8-Oxo-dG.

Keywords

• Ionizing radiation
• Radiation injury
• Biodosimeter
• Comet assay
• Dicentric chromosome aberration
• γ-H2AX