Терапевтический архив (Feb 2016)

Seronegative celiac disease: A case report

  • L M Krums,
  • A I Parfenov,
  • E A Sabelnikova,
  • N I Poleva,
  • S V Bykova,
  • E A Dubtsova,
  • R B Gudkova,
  • S G Khomeriki,
  • D L Rotin,
  • M V Pavlov,
  • N S Starostina

Journal volume & issue
Vol. 88, no. 2
pp. 75 – 77

Abstract

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The paper describes a rare case of celiac disease in the absence of serum anti-tissue transglutaminase (anti-tTG) antibodies. A 51-year-old patient has been suffering from diarrheas for 20 years. He has lost 15 kg gradually; weakness progressed; muscle cramps, leg edemas, and signs of dynamic pseudoobstruction appeared. Morphological examination revealed small intestinal mucosal (SIM) villous atrophy (Marsh IIIC stage). IgA anti-tTG and IgG anti-tTG antibodies were 0.086 and 0.178, respectively. The patient was prescribed a gluten-free diet, water electrolyte solutions to correct metabolic disturbances, and prednisolone. During a control examination after 6 months, the patient had no complaints and gained 22 kg, and the SIM villus height was increased. The specific feature of the case is specific negative serological tests for celiac disease.

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