RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity

Sumin Feng; Sai Ma; Kejiao Li; Shengxian Gao; Shaokai Ning; Jinfeng Shang; Ruiyuan Guo; Yingying Chen; Britny Blumenfeld; Itamar Simon; Qing Li; Rong Guo; Dongyi Xu

doi:10.1038/s41467-022-28588-y

Nature Communications (Feb 2022)

RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity

Sumin Feng,
Sai Ma,
Kejiao Li,
Shengxian Gao,
Shaokai Ning,
Jinfeng Shang,
Ruiyuan Guo,
Yingying Chen,
Britny Blumenfeld,
Itamar Simon,
Qing Li,
Rong Guo,
Dongyi Xu

Affiliations

Sumin Feng: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Sai Ma: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Kejiao Li: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Shengxian Gao: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Shaokai Ning: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Jinfeng Shang: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Ruiyuan Guo: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Yingying Chen: Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University
Britny Blumenfeld: Department of Microbiology and Molecular Genetics, Institute of Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University
Itamar Simon: Department of Microbiology and Molecular Genetics, Institute of Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University
Qing Li: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Rong Guo: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Dongyi Xu: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University

DOI: https://doi.org/10.1038/s41467-022-28588-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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The 53BP1-RIF1 pathway is important for DNA repair. Here, the authors identified the histone chaperone ASF1, which functions as a suppressor of DNA end resection through changing high-order chromatin structure, as a partner of RIF1. This finding links DNA repair and dynamic changes of high-order chromatin structure.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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