Nature Communications (May 2016)

Rational design of a protein that binds integrin αvβ3 outside the ligand binding site

  • Ravi Chakra Turaga,
  • Lu Yin,
  • Jenny J. Yang,
  • Hsiauwei Lee,
  • Ivaylo Ivanov,
  • Chunli Yan,
  • Hua Yang,
  • Hans E. Grossniklaus,
  • Siming Wang,
  • Cheng Ma,
  • Li Sun,
  • Zhi-Ren Liu

DOI
https://doi.org/10.1038/ncomms11675
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

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Integrins are transmembrane proteins that have important roles in cell adhesion and signalling. Here the authors design a therapeutic protein that binds integrin αvβ3, has anti-angiogenic activity, and reduces tumour growth in xenograft models, while being seemingly well tolerated.