Nature Communications (May 2016)
Rational design of a protein that binds integrin αvβ3 outside the ligand binding site
Abstract
Integrins are transmembrane proteins that have important roles in cell adhesion and signalling. Here the authors design a therapeutic protein that binds integrin αvβ3, has anti-angiogenic activity, and reduces tumour growth in xenograft models, while being seemingly well tolerated.