Frontiers in Bioengineering and Biotechnology (Feb 2018)

The Role of Noncoding RNA Pseudouridylation in Nuclear Gene Expression Events

  • Yang Zhao,
  • William Dunker,
  • Yi-Tao Yu,
  • John Karijolich,
  • John Karijolich

DOI
https://doi.org/10.3389/fbioe.2018.00008
Journal volume & issue
Vol. 6

Abstract

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Pseudouridine is the most abundant internal RNA modification in stable noncoding RNAs (ncRNAs). It can be catalyzed by both RNA-dependent and RNA-independent mechanisms. Pseudouridylation impacts both the biochemical and biophysical properties of RNAs and thus influences RNA-mediated cellular processes. The investigation of nuclear-ncRNA pseudouridylation has demonstrated that it is critical for the proper control of multiple stages of gene expression regulation. Here, we review how nuclear-ncRNA pseudouridylation contributes to transcriptional regulation and pre-mRNA splicing.

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