Intrinsic cell rheology drives junction maturation

K. Sri-Ranjan; J. L. Sanchez-Alonso; P. Swiatlowska; S. Rothery; P. Novak; S. Gerlach; D. Koeninger; B. Hoffmann; R. Merkel; M. M. Stevens; S. X. Sun; J. Gorelik; Vania M. M. Braga

doi:10.1038/s41467-022-32102-9

Nature Communications (Aug 2022)

Intrinsic cell rheology drives junction maturation

K. Sri-Ranjan,
J. L. Sanchez-Alonso,
P. Swiatlowska,
S. Rothery,
P. Novak,
S. Gerlach,
D. Koeninger,
B. Hoffmann,
R. Merkel,
M. M. Stevens,
S. X. Sun,
J. Gorelik,
Vania M. M. Braga

Affiliations

K. Sri-Ranjan: National Heart and Lung Institute, Faculty of Medicine, Imperial College London
J. L. Sanchez-Alonso: National Heart and Lung Institute, Faculty of Medicine, Imperial College London
P. Swiatlowska: National Heart and Lung Institute, Faculty of Medicine, Imperial College London
S. Rothery: National Heart and Lung Institute, Faculty of Medicine, Imperial College London
P. Novak: School of Engineering and Materials Science, Queen Mary University
S. Gerlach: Institute of Biological Information Processing, IBI-2: Mechanobiology
D. Koeninger: Institute of Biological Information Processing, IBI-2: Mechanobiology
B. Hoffmann: Institute of Biological Information Processing, IBI-2: Mechanobiology
R. Merkel: Institute of Biological Information Processing, IBI-2: Mechanobiology
M. M. Stevens: Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering Imperial College London
S. X. Sun: Department of Mechanical Engineering and Institute of NanoBioTechnology, Johns Hopkins University
J. Gorelik: National Heart and Lung Institute, Faculty of Medicine, Imperial College London
Vania M. M. Braga: National Heart and Lung Institute, Faculty of Medicine, Imperial College London

DOI: https://doi.org/10.1038/s41467-022-32102-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

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How intrinsic cell properties such as stiffness contribute to cell-cell junction stabilization is not well described. Here they show that higher levels of intrinsic cell mechanics at the cortex, cytoskeleton and nucleus of neighboring cells promote junctional maturation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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