Nature Communications (Sep 2020)
Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics
Abstract
Here the authors use chemical proteomics to identify the herpes simplex virus 1 encoded proteome in infected cells. Functional characterization of one of the nine identified proteins, designated piUL49, shows that it acts as neurovirulence factor in mice by regulating a virally encoded dUTPase.