Nature Communications (Sep 2020)

Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics

  • Akihisa Kato,
  • Shungo Adachi,
  • Shuichi Kawano,
  • Kousuke Takeshima,
  • Mizuki Watanabe,
  • Shinobu Kitazume,
  • Ryota Sato,
  • Hideo Kusano,
  • Naoto Koyanagi,
  • Yuhei Maruzuru,
  • Jun Arii,
  • Tomohisa Hatta,
  • Tohru Natsume,
  • Yasushi Kawaguchi

DOI
https://doi.org/10.1038/s41467-020-18718-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Here the authors use chemical proteomics to identify the herpes simplex virus 1 encoded proteome in infected cells. Functional characterization of one of the nine identified proteins, designated piUL49, shows that it acts as neurovirulence factor in mice by regulating a virally encoded dUTPase.