Low Antimicrobial Resistance of Shigella Isolates In a Tertiary Care Hospital in Ahmedabad, Gujarat- A 3 Year Study

Abstract

Background and objectives: Shigella play an important role as a causative organism of acute gastroenteritis, which is a global health problem with significant morbidity and mortality especially in developing countries and also is the most communicable of the bacterial diarrheas. The purpose of present study was to determine the incidence of Shigella species and their antimicrobial resistance patterns in the patients presenting with acute gastroenteritis to our tertiary care centre in Ahmedabad. Materials and methods: The study included all patients with acute gastroenteritis who visited a tertiary care hospital in Ahmedabad during a 3-year period (Jan’ 2013- Dec’15). The isolates was confirmed as Shigella by biochemical reaction and slide agglutination test using specific antisera. Antibiotic sensitivity was determined by Kirby-Bauer disc diffusion method as per CLSI guidelines. Discussion and conclusion: The predominant Shigella species isolated in this study was Shigella flexneri. The present study demonstrates that Shigella species showing significant increase in resistance to several commonly used antimicrobial agents like ampicillin, cotrimoxazole and chloramphenicol but still very less resistance for fluoroquinolones and 3rd generation cephalosporins.

Keywords

• Shigella
• gastroenteritis
• resistance