Effect of Ishophloroglucin A, A Component of <i>Ishige okamurae</i>, on Glucose Homeostasis in the Pancreas and Muscle of High Fat Diet-Fed Mice
Hye-Won Yang,
Myeongjoo Son,
Junwon Choi,
Seyeon Oh,
You-Jin Jeon,
Kyunghee Byun,
BoMi Ryu
Affiliations
Hye-Won Yang
Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, 1 Ara 1-dong, Jejudaehak-ro, Jeju 63243, Korea
Myeongjoo Son
Department of Anatomy & Cell Biology, Gachon University College of Medicine, Incheon 21936, Korea
Junwon Choi
Department of Anatomy & Cell Biology, Gachon University College of Medicine, Incheon 21936, Korea
Seyeon Oh
Functional Cellular Networks Laboratory, College of Medicine, Department of Medicine, Graduate School and Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea
You-Jin Jeon
Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, 1 Ara 1-dong, Jejudaehak-ro, Jeju 63243, Korea
Kyunghee Byun
Department of Anatomy & Cell Biology, Gachon University College of Medicine, Incheon 21936, Korea
BoMi Ryu
Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, 1 Ara 1-dong, Jejudaehak-ro, Jeju 63243, Korea
Ishophloroglucin A (IPA), a component of Ishige okamurae (IO), was previously evaluated to standardize the antidiabetic potency of IO. However, the potential of IPA as a functional food for diabetes prevention has not yet been evaluated. Here, we investigated if 1.35 mg/kg IPA, which is the equivalent content of IPA in 75 mg/kg IO, improved glucose homeostasis in high-fat diet (HFD)-induced diabetes after 12 weeks of treatment. IPA significantly ameliorated glucose intolerance, reducing fasting glucose levels as well as 2 h glucose levels in HFD mice. In addition, IPA exerted a protective effect on the pancreatic function in HFD mice via pancreatic β-cells and C-peptide. The level of glucose transporter 4 (GLUT4) in the muscles of HFD mice was stimulated by IPA intake. Our results suggested that IPA, which is a component of IO, can improve glucose homeostasis via GLUT4 in the muscles of HFD mice. IO may be used as a functional food for the prevention of diabetes.
