A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2

Alisa A. Garaeva; Albert Guskov; Dirk J. Slotboom; Cristina Paulino

doi:10.1038/s41467-019-11363-x

Nature Communications (Jul 2019)

A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2

Alisa A. Garaeva,
Albert Guskov,
Dirk J. Slotboom,
Cristina Paulino

Affiliations

Alisa A. Garaeva: Membrane Enzymology, University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute
Albert Guskov: Structural Biology, University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute
Dirk J. Slotboom: Membrane Enzymology, University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute
Cristina Paulino: Membrane Enzymology, University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute

DOI: https://doi.org/10.1038/s41467-019-11363-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

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How the human Alanine Serine Cysteine Transporter 2 (ASCT2) binds its substrates, neutral amino acids, and releases them on the cytoplasmic side remains unclear. Here authors present an inward-open structure of the human ASCT2 which shows that a hairpin serves as a gate in the inward-facing state.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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