Data describing child development at 6 years after maternal cancer diagnosis and treatment during pregnancy
Mathilde van Gerwen,
Tineke Vandenbroucke,
Magali Verheecke,
Kristel Van Calsteren,
Michael J. Halaska,
Monica Fumagalli,
Robert Fruscio,
Amarendra Gandhi,
Margreet Veening,
Lieven Lagae,
Petronella B. Ottevanger,
Jens-Uwe Voigt,
Jorine de Haan,
Mina M. Gziri,
Charlotte Maggen,
Luc Mertens,
Gunnar Naulaers,
Laurence Claes,
Frédéric Amant
Affiliations
Mathilde van Gerwen
Center for Gynecologic Oncology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands; Princess Máxima Center for pediatric oncology, Utrecht, the Netherlands; Corresponding author at: Division of Gynecologic Oncology, University Hospitals Leuven, and Department of Oncology, KU Leuven, Belgium, Herestraat 49, 3000 Leuven, Belgium.
Tineke Vandenbroucke
Department of Obstetrics and Gynecology, University Hospitals Leuven; Department of Oncology, KU Leuven, Leuven, Belgium; Corresponding author at: Division of Gynecologic Oncology, University Hospitals Leuven, and Department of Oncology, KU Leuven, Belgium, Herestraat 49, 3000 Leuven, Belgium.
Magali Verheecke
Department of Obstetrics and Gynecology, University Hospitals Leuven; Department of Oncology, KU Leuven, Leuven, Belgium
Kristel Van Calsteren
Department of Obstetrics and Gynecology, University Hospitals Leuven; Department of Development and Regeneration, KU Leuven, Leuven, Belgium
Michael J. Halaska
Department of Obstetrics and Gynecology, 3rd Medical Faculty Charles University Faculty Hospital Kralovske Vinohrady, Prague, Czech Republic
Monica Fumagalli
Neonatal Intensive Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico and Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Robert Fruscio
Clinic of Obstetrics and Gynecology, University of Milan-Bicocca and San Gerardo Hospital, Monza, Italy
Amarendra Gandhi
Department of Public Health and Primary Care, Faculty of Medicine, KU Leuven, Leuven and Data Scientist, Knowledge Center, SD Worx, Antwerp, Belgium
Margreet Veening
Princess Máxima Center for pediatric oncology, Utrecht, the Netherlands
Lieven Lagae
Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium
Petronella B. Ottevanger
Department of Internal Medicine, Radboud UMC Nijmegen, the Netherlands
Jens-Uwe Voigt
Department of Cardiology, University Hospitals Leuven, Leuven, Belgium
Jorine de Haan
Department of Obstetrics and Gynecology, Amsterdam UMC, Location VU University Medical Center, the Netherlands
Mina M. Gziri
Department of Obstetrics, Cliniques Universitaires St Luc, Brussels, Belgium
Charlotte Maggen
Department of Obstetrics and Gynecology, University Hospitals Leuven; Department of Oncology, KU Leuven, Leuven, Belgium
Luc Mertens
Department of Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Gunnar Naulaers
Department of Neonatology, University Hospitals Leuven, Leuven, Belgium
Laurence Claes
Faculty of Psychology and Educational Sciences, KU Leuven, Leuven, Belgium
Frédéric Amant
Center for Gynecologic Oncology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands; Department of Oncology, KU Leuven, Leuven, Belgium; Department of Obstetrics and Gynecology, Amsterdam UMC, Location Amsterdam Medical Center and University of Amsterdam, the Netherlands
This manuscript is an accompanying resource of the original research article entitled “Child development at 6 years after maternal cancer diagnosis and treatment during pregnancy” and present data that compare the outcome of 6-year-old-children born to women diagnosed with cancer during pregnancy (with or without treatment during pregnancy) (study group) with children born after an uncomplicated pregnancy (control group). Oncological, obstetrical and neonatal data were collected. Neurodevelopment was examined by clinical evaluation and neuropsychological testing (including intelligence, attention and memory tests) and by general health and behavior questionnaires. Cardiac evaluation included electro- and echocardiography. Univariate analyses of covariance were used to investigate between-group differences. A subgroup analysis was performed in chemotherapy-exposed children versus controls and anthracycline-exposed versus controls. Additionally, the incidence of behaviour problems was compared to matched controls for children whose mothers died and for those with surviving mothers.
