Chemical Diversity and Biological Activities of Marine Sponges of the Genus <i>Suberea</i>: A Systematic Review
Amr El-Demerdash,
Atanas G. Atanasov,
Olaf K. Horbanczuk,
Mohamed A. Tammam,
Mamdouh Abdel-Mogib,
John N. A. Hooper,
Nazim Sekeroglu,
Ali Al-Mourabit,
Anake Kijjoa
Affiliations
Amr El-Demerdash
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, University of Paris-Saclay, 1, Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France
Atanas G. Atanasov
Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria
Olaf K. Horbanczuk
Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences, 02-776 Warsaw, Poland
Mohamed A. Tammam
Department of Pharmacognosy and chemistry of natural products, Faculty of Pharmacy, National and kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Queensland Museum, P.O. Box 3300, South Brisbane BC, QLD 4101, Australia
Nazim Sekeroglu
Department of Food Engineering, Faculty of Engineering and Architecture, Killis 7 Aralik University, 79000 Kilis, Turkey
Ali Al-Mourabit
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, University of Paris-Saclay, 1, Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France
Anake Kijjoa
ICBAS—Instituto de Ciências Biomédicas Abel Salazar & CIIMAR, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus Suberea (family: Aplysinellidae) are recognized as producers of bromotyrosine derivatives, which are considered distinct chemotaxonomic markers for the marine sponges belonging to the order Verongida. This class of compounds exhibits structural diversity, ranging from simple monomeric molecules to more complex molecular scaffolds, displaying a myriad of biological and pharmacological potentialities. In this review, a comprehensive literature survey covering the period of 1998⁻2018, focusing on the chemistry and biological/pharmacological activities of marine natural products from marine sponges of the genus Suberea, with special attention to the biogenesis of the different skeletons of halogenated compounds, is presented.
