SYNTHESES AND ANTIOXIDANT ACTIVITIES OF SOME HYDROXY DIMETHOXY CHALCONE DERIVATIVES

Abstract

Four (4) hydroxy dimethoxy chalcones derivatives were synthesized by Claisen-Schmidt condensation of hydroxyacetophenone with 3,4-dimethoxybenzaldehyde using conventional method and grinding technique. The synthesized compounds were characterized by spectroscopy (IR, 1H-NMR and 13C-NMR). Synthesis of the hydroxy dimethoxy chalcone using grinding method is better than the conventional method. The synthesis using grinding method require a low concentration base, shorter reaction (15min) and higher yield (70-84%). The antioxidant activity of the compounds was determined by DPPH method, showed that 2',5'-dihydroxy-3,4-dimethoxy chalcone have the highest antioxidant activity.

Keywords

• hydroxy dimethoxy chalcone
• Claisen-Schmidt condensation
• grinding
• DPPH method