Crosstalk between CST and RPA regulates RAD51 activity during replication stress

Kai-Hang Lei; Han-Lin Yang; Hao-Yen Chang; Hsin-Yi Yeh; Dinh Duc Nguyen; Tzu-Yu Lee; Xinxing Lyu; Megan Chastain; Weihang Chai; Hung-Wen Li; Peter Chi

doi:10.1038/s41467-021-26624-x

Nature Communications (Nov 2021)

Crosstalk between CST and RPA regulates RAD51 activity during replication stress

Kai-Hang Lei,
Han-Lin Yang,
Hao-Yen Chang,
Hsin-Yi Yeh,
Dinh Duc Nguyen,
Tzu-Yu Lee,
Xinxing Lyu,
Megan Chastain,
Weihang Chai,
Hung-Wen Li,
Peter Chi

Affiliations

Kai-Hang Lei: Institute of Biochemical Sciences, National Taiwan University
Han-Lin Yang: Department of Chemistry, National Taiwan University
Hao-Yen Chang: Institute of Biochemical Sciences, National Taiwan University
Hsin-Yi Yeh: Institute of Biochemical Sciences, National Taiwan University
Dinh Duc Nguyen: Department of Cancer Biology, Cardinal Bernardin Cancer Center, Loyola University Chicago Stritch School of Medicine
Tzu-Yu Lee: Department of Chemistry, National Taiwan University
Xinxing Lyu: Department of Cancer Biology, Cardinal Bernardin Cancer Center, Loyola University Chicago Stritch School of Medicine
Megan Chastain: Office of Research, Washington State University
Weihang Chai: Department of Cancer Biology, Cardinal Bernardin Cancer Center, Loyola University Chicago Stritch School of Medicine
Hung-Wen Li: Department of Chemistry, National Taiwan University
Peter Chi: Institute of Biochemical Sciences, National Taiwan University

DOI: https://doi.org/10.1038/s41467-021-26624-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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During replication stress, the RPA protein complex coats single-stranded DNA to preclude RAD51 loading. Here, the authors show how RPA and CST crosstalk to regulate RAD51 activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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