Journal of Analytical Methods in Chemistry (Jan 2015)

General Analytical Procedure for Determination of Acidity Parameters of Weak Acids and Bases

  • Bogusław Pilarski,
  • Roman Kaliszan,
  • Dariusz Wyrzykowski,
  • Janusz Młodzianowski,
  • Agata Balińska

DOI
https://doi.org/10.1155/2015/530731
Journal volume & issue
Vol. 2015

Abstract

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The paper presents a new convenient, inexpensive, and reagent-saving general methodology for the determination of pKa values for components of the mixture of diverse chemical classes weak organic acids and bases in water solution, without the need to separate individual analytes. The data obtained from simple pH-metric microtitrations are numerically processed into reliable pKa values for each component of the mixture. Excellent agreement has been obtained between the determined pKa values and the reference literature data for compounds studied.