Albumin in patients with liver disease shows an altered conformation

Margret Paar; Vera H. Fengler; Daniel J. Rosenberg; Angelika Krebs; Rudolf E. Stauber; Karl Oettl; Michal Hammel

doi:10.1038/s42003-021-02269-w

Communications Biology (Jun 2021)

Albumin in patients with liver disease shows an altered conformation

Margret Paar,
Vera H. Fengler,
Daniel J. Rosenberg,
Angelika Krebs,
Rudolf E. Stauber,
Karl Oettl,
Michal Hammel

Affiliations

Margret Paar: Division of Physiological Chemistry, Otto-Loewi Research Center, Medical University of Graz
Vera H. Fengler: Division of Physiological Chemistry, Otto-Loewi Research Center, Medical University of Graz
Daniel J. Rosenberg: Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory
Angelika Krebs: Science Technology Interface–Structural Biology, Center for Medical Research, Medical University of Graz
Rudolf E. Stauber: Department of Internal Medicine, Medical University of Graz
Karl Oettl: Division of Physiological Chemistry, Otto-Loewi Research Center, Medical University of Graz
Michal Hammel: Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory

DOI: https://doi.org/10.1038/s42003-021-02269-w
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 9

Abstract

Read online

Paar et al. propose a SAXS-based approach to study conformations of human serum albumin (HSA) from patients with liver disease and a structural understanding of HSA dynamicity and its correlation with clinical variables are provided. Using it on real clinical samples, this study has concrete practical implications too.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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