An Unusual Case of Immune Complex-Mediated Membranoproliferative Glomerulonephritis as Renal Manifestation of Idiopathic Hypereosinophilic Syndrome: A Case Report and Literature Review
Michael Cieza-Terrones,
José C. De La Flor,
Christian Requejo,
Daniel Villa,
Jacqueline Apaza,
Pablo Rodríguez-Doyágüez,
Rocío Zamora,
Carmen Asato-Higa,
David Rivera-Estrella,
Antonio Carrasco-Yalán
Affiliations
Michael Cieza-Terrones
Department of Nephrology, Hospital Cayetano Heredia, Faculty of Medicine, Peruana Cayetano Heredia University, Lima 15002, Peru
José C. De La Flor
Department of Nephrology, Hospital Central Defense Gomez Ulla, 280467 Madrid, Spain
Christian Requejo
Department of Nephrology, Hospital Cayetano Heredia, Faculty of Medicine, Peruana Cayetano Heredia University, Lima 15002, Peru
Daniel Villa
Department of Nephrology, Clínica Universidad de Navarra, 31008 Navarra, Spain
Jacqueline Apaza
Department of Nephrology, Hospital Rey Juan Carlos, 28933 Madrid, Spain
Pablo Rodríguez-Doyágüez
Department of Nephrology, Guadalajara Center Dialysis, AVERICUM, 19003 Guadalajara, Spain
Rocío Zamora
Department of Nephrology, Hospital Universitario General Villalba, 28400 Madrid, Spain
Carmen Asato-Higa
Anatomic Pathology Department, PATOLOGAS AS SAC, Lima 15082, Peru
David Rivera-Estrella
Department of Nephrology, Hospital Cayetano Heredia, Faculty of Medicine, Peruana Cayetano Heredia University, Lima 15002, Peru
Antonio Carrasco-Yalán
Postgraduate School, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15081, Peru
Background: Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by abnormal and persistent peripheral blood hypereosinophilia (eosinophil count ≥ 1.5 × 109/L and ≥10% eosinophils) with duration ≥ 6 months, associated organ damage, and/or dysfunction attributable to tissue eosinophilic infiltrate of unknown cause. IHES affects different organs such as the heart, lungs, nervous system, and skin, with renal involvement being rare in this condition. Case Presentation: We present a case of a young patient with IHES and immune complex-mediated membranoproliferative glomerulonephritis with nephrotic syndrome, as a rare renal manifestation. We discuss the clinical, analytical, and histopathologic renal and hematologic features, comparing them with other reported cases in the literature.