Medicines (Jun 2024)

An Unusual Case of Immune Complex-Mediated Membranoproliferative Glomerulonephritis as Renal Manifestation of Idiopathic Hypereosinophilic Syndrome: A Case Report and Literature Review

  • Michael Cieza-Terrones,
  • José C. De La Flor,
  • Christian Requejo,
  • Daniel Villa,
  • Jacqueline Apaza,
  • Pablo Rodríguez-Doyágüez,
  • Rocío Zamora,
  • Carmen Asato-Higa,
  • David Rivera-Estrella,
  • Antonio Carrasco-Yalán

DOI
https://doi.org/10.3390/medicines11060013
Journal volume & issue
Vol. 11, no. 6
p. 13

Abstract

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Background: Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by abnormal and persistent peripheral blood hypereosinophilia (eosinophil count ≥ 1.5 × 109/L and ≥10% eosinophils) with duration ≥ 6 months, associated organ damage, and/or dysfunction attributable to tissue eosinophilic infiltrate of unknown cause. IHES affects different organs such as the heart, lungs, nervous system, and skin, with renal involvement being rare in this condition. Case Presentation: We present a case of a young patient with IHES and immune complex-mediated membranoproliferative glomerulonephritis with nephrotic syndrome, as a rare renal manifestation. We discuss the clinical, analytical, and histopathologic renal and hematologic features, comparing them with other reported cases in the literature.

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