Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice

Wenqian He; Chi-Jene Chen; Caitlin E. Mullarkey; Jennifer R. Hamilton; Christine K. Wong; Paul E. Leon; Melissa B. Uccellini; Veronika Chromikova; Carole Henry; Kevin W. Hoffman; Jean K. Lim; Patrick C. Wilson; Matthew S. Miller; Florian Krammer; Peter Palese; Gene S. Tan

doi:10.1038/s41467-017-00928-3

Nature Communications (Oct 2017)

Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice

Wenqian He,
Chi-Jene Chen,
Caitlin E. Mullarkey,
Jennifer R. Hamilton,
Christine K. Wong,
Paul E. Leon,
Melissa B. Uccellini,
Veronika Chromikova,
Carole Henry,
Kevin W. Hoffman,
Jean K. Lim,
Patrick C. Wilson,
Matthew S. Miller,
Florian Krammer,
Peter Palese,
Gene S. Tan

Affiliations

Wenqian He: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Chi-Jene Chen: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Caitlin E. Mullarkey: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Jennifer R. Hamilton: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Christine K. Wong: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Paul E. Leon: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Melissa B. Uccellini: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Veronika Chromikova: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Carole Henry: Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The Committee on Immunology, The University of Chicago
Kevin W. Hoffman: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Jean K. Lim: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Patrick C. Wilson: Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The Committee on Immunology, The University of Chicago
Matthew S. Miller: Department of Biochemistry and Biomedical Sciences, Institute of Infectious Diseases Research, McMaster Immunology Research Centre, McMaster University
Florian Krammer: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Peter Palese: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Gene S. Tan: Department of Microbiology, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-017-00928-3
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Broadly reactive antibodies that recognize influenza A virus HA can be protective, but the mechanism is not completely understood. Here, He et al. show that the inflammatory response and phagocytosis mediated by the interaction between protective antibodies and macrophages are essential for protection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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