Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization

Shiho Chiba; Steven J. Frey; Peter J. Halfmann; Makoto Kuroda; Tadashi Maemura; Jie E. Yang; Elizabeth R. Wright; Yoshihiro Kawaoka; Ravi S. Kane

doi:10.1038/s42003-021-02128-8

Communications Biology (May 2021)

Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization

Shiho Chiba,
Steven J. Frey,
Peter J. Halfmann,
Makoto Kuroda,
Tadashi Maemura,
Jie E. Yang,
Elizabeth R. Wright,
Yoshihiro Kawaoka,
Ravi S. Kane

Affiliations

Shiho Chiba: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin
Steven J. Frey: School of Chemical & Biomolecular Engineering, Georgia Institute of Technology
Peter J. Halfmann: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin
Makoto Kuroda: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin
Tadashi Maemura: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin
Jie E. Yang: Department of Biochemistry, University of Wisconsin
Elizabeth R. Wright: Department of Biochemistry, University of Wisconsin
Yoshihiro Kawaoka: Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin
Ravi S. Kane: School of Chemical & Biomolecular Engineering, Georgia Institute of Technology

DOI: https://doi.org/10.1038/s42003-021-02128-8
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 9

Abstract

Read online

Chiba et al. describe the use of MS2 bacteriophage coat proteins to develop nanocarriers that display the SARS-CoV-2 spike proteins multivalently for vaccine applications. The vaccine elicited high neutralizing antibody titers and protected Syrian hamsters from virus infection after a single immunization.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal