Frontiers in Endocrinology (Sep 2022)
The prevalence of MAFLD and its association with atrial fibrillation in a nationwide health check-up population in China
- Fang Lei,
- Fang Lei,
- Juan-Juan Qin,
- Juan-Juan Qin,
- Xiaohui Song,
- Xiaohui Song,
- Ye-Mao Liu,
- Ye-Mao Liu,
- Ye-Mao Liu,
- Ming-Ming Chen,
- Ming-Ming Chen,
- Tao Sun,
- Tao Sun,
- Xuewei Huang,
- Xuewei Huang,
- Ke-Qiong Deng,
- Ke-Qiong Deng,
- Ke-Qiong Deng,
- Xiuran Zuo,
- Dongai Yao,
- Li-Juan Xu,
- Huiming Lu,
- Gang Wang,
- Feng Liu,
- Lidong Chen,
- Jie Luo,
- Jiahong Xia,
- Lin Wang,
- QiongYu Yang,
- Peng Zhang,
- Peng Zhang,
- Yan-Xiao Ji,
- Yan-Xiao Ji,
- Xiao-Jing Zhang,
- Xiao-Jing Zhang,
- Zhi-Gang She,
- Zhi-Gang She,
- Qiang Zeng,
- Hongliang Li,
- Hongliang Li,
- Hongliang Li,
- Hongliang Li,
- Jingjing Cai,
- Jingjing Cai
Affiliations
- Fang Lei
- Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China
- Fang Lei
- Institute of Model Animal, Wuhan University, Wuhan, China
- Juan-Juan Qin
- Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China
- Juan-Juan Qin
- Institute of Model Animal, Wuhan University, Wuhan, China
- Xiaohui Song
- Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China
- Xiaohui Song
- Institute of Model Animal, Wuhan University, Wuhan, China
- Ye-Mao Liu
- Institute of Model Animal, Wuhan University, Wuhan, China
- Ye-Mao Liu
- Department of Cardiology, Huanggang Central Hospital, Huanggang, China
- Ye-Mao Liu
- Huanggang Institute of Translational Medicine, Huanggang Central Hospital, Huanggang, China
- Ming-Ming Chen
- Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China
- Ming-Ming Chen
- Institute of Model Animal, Wuhan University, Wuhan, China
- Tao Sun
- Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China
- Tao Sun
- Institute of Model Animal, Wuhan University, Wuhan, China
- Xuewei Huang
- Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China
- Xuewei Huang
- Institute of Model Animal, Wuhan University, Wuhan, China
- Ke-Qiong Deng
- Department of Cardiology, Huanggang Central Hospital, Huanggang, China
- Ke-Qiong Deng
- Huanggang Institute of Translational Medicine, Huanggang Central Hospital, Huanggang, China
- Ke-Qiong Deng
- Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China
- Xiuran Zuo
- Department of Information, The Central Hospital of Wuhan, Wuhan, China
- Dongai Yao
- Physical Examination Center, Zhongnan Hospital of Wuhan University, Wuhan, China
- Li-Juan Xu
- Physical Examination Center, Renmin Hospital, Wuhan University, Wuhan, China
- Huiming Lu
- General Medical Department, CR & WISCO General Hospital, Wuhan, China
- Gang Wang
- 0Basic Medical Laboratory, General Hospital of Central Theater Command, Wuhan, China
- Feng Liu
- 1Information Center, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, China
- Lidong Chen
- 2Department of Medical Examination Center, Taihe Hospital, Hubei University of Medicine, Shiyan, China
- Jie Luo
- 3Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China
- Jiahong Xia
- 4Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Lin Wang
- 5Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi’an, China
- QiongYu Yang
- 6Chinese Medicine Center, Shiyan Renmin Hospital, Shiyan, China
- Peng Zhang
- Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China
- Peng Zhang
- Institute of Model Animal, Wuhan University, Wuhan, China
- Yan-Xiao Ji
- Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China
- Yan-Xiao Ji
- Institute of Model Animal, Wuhan University, Wuhan, China
- Xiao-Jing Zhang
- Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China
- Xiao-Jing Zhang
- Institute of Model Animal, Wuhan University, Wuhan, China
- Zhi-Gang She
- Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China
- Zhi-Gang She
- Institute of Model Animal, Wuhan University, Wuhan, China
- Qiang Zeng
- 7Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China
- Hongliang Li
- Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China
- Hongliang Li
- Institute of Model Animal, Wuhan University, Wuhan, China
- Hongliang Li
- Huanggang Institute of Translational Medicine, Huanggang Central Hospital, Huanggang, China
- Hongliang Li
- 8Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China
- Jingjing Cai
- Institute of Model Animal, Wuhan University, Wuhan, China
- Jingjing Cai
- 9Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fendo.2022.1007171
- Journal volume & issue
-
Vol. 13
Abstract
Background and aimsThe epidemiological characteristics of MAFLD and its relationship with atrial fibrillation (AF) are limited in China. Therefore, we explored the epidemiological characteristics of MAFLD from adults along with the association of MAFLD and 12-ECG diagnosed AF in a nationwide population from health check-up centers.MethodsThis observational study used cross-sectional and longitudinal studies with 2,083,984 subjects from 2009 to 2017. Age-, sex-, and regional-standardized prevalence of MAFLD was estimated. Latent class analysis (LCA) was used to identify subclusters of MAFLD. Multivariable logistic regression and mixed-effects Cox regression models were used to analyze the relationship between MAFLD and AF.ResultsThe prevalence of MAFLD increased from 22.75% to 35.58% during the study period, with higher rates in males and populations with high BMI or resided in northern regions. The MAFLD population was clustered into three classes with different metabolic features by LCA. Notably, a high proportion of MAFLD patients in all clusters had overweight and prediabetes or diabetes. The MAFLD was significantly associated with a higher risk of AF in the cross-sectional study and in the longitudinal study. In addition, the coexistence of prediabetes or diabetes had the largest impact on subsequent AF.ConclusionOur findings suggested a high prevalence of MAFLD and a high prevalence of other metabolic diseases in the MAFLD population, particularly overweight and glucose dysregulation. Moreover, MAFLD was associated with a significantly higher risk for existing and subsequent subclinical AF in the Chinese population.
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