Effect of Cucumis sativus L on Glucose Absorption through Intestinal Mucosal Membrane of Wistar Rat Models

Abstract

Background: The Cucumis sativus L has been used in traditional medicine for several conditions, with one of them being diabetes mellitus. The purpose of this experiment is to observe the anti-hyperglycemic effect of Cucumis sativus L on glucose absorption through the intestinal mucosal membrane of Wistar rats. Methods: The research was conducted on September–November 2012 at Biochemistry Laboratory, Faculty of Medicine, Universitas Padjadjaran. Using in situ perfusion method, the rat’s epithelial mucosa in the intestine was bathed in a simple glucose solution in control, and bathed in glucose and Cucumis sativus L infusion in treatment. After admission, a sample was taken from the digestive tract and the glucose level was measured through a spectrophotometer. Result: There is no significant difference in the absorption of control and treatment solution. Conclusion: The Cucumis sativus L does not have any significant effect on the glucose absorption through the intestinal mucosal membrane. Further studies are still needed to reveal the antihyperglycemic mechanism of Cucumis sativus L.[AMJ.2014;1(1):30–4]

Keywords

• Antihyperglycemic effect
• Cucumis sativus L (Cucumber)
• Diabetes mellitus
• Glucose absorption