Nature Communications (Apr 2021)
Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase
- Simon Bo Jensen,
- Sara Thodberg,
- Shaheena Parween,
- Matias E. Moses,
- Cecilie C. Hansen,
- Johannes Thomsen,
- Magnus B. Sletfjerding,
- Camilla Knudsen,
- Rita Del Giudice,
- Philip M. Lund,
- Patricia R. Castaño,
- Yanet G. Bustamante,
- Maria Natalia Rojas Velazquez,
- Flemming Steen Jørgensen,
- Amit V. Pandey,
- Tomas Laursen,
- Birger Lindberg Møller,
- Nikos S. Hatzakis
Affiliations
- Simon Bo Jensen
- Department of Chemistry & Nanoscience Centre, University of Copenhagen
- Sara Thodberg
- Plant Biochemistry Laboratory, Department of Plant and Environmental Sciences, University of Copenhagen
- Shaheena Parween
- Pediatric Endocrinology, Diabetology, and Metabolism, University Children’s Hospital
- Matias E. Moses
- Department of Chemistry & Nanoscience Centre, University of Copenhagen
- Cecilie C. Hansen
- Plant Biochemistry Laboratory, Department of Plant and Environmental Sciences, University of Copenhagen
- Johannes Thomsen
- Department of Chemistry & Nanoscience Centre, University of Copenhagen
- Magnus B. Sletfjerding
- Department of Chemistry & Nanoscience Centre, University of Copenhagen
- Camilla Knudsen
- Plant Biochemistry Laboratory, Department of Plant and Environmental Sciences, University of Copenhagen
- Rita Del Giudice
- Plant Biochemistry Laboratory, Department of Plant and Environmental Sciences, University of Copenhagen
- Philip M. Lund
- Department of Chemistry & Nanoscience Centre, University of Copenhagen
- Patricia R. Castaño
- Pediatric Endocrinology, Diabetology, and Metabolism, University Children’s Hospital
- Yanet G. Bustamante
- Department of Chemistry & Nanoscience Centre, University of Copenhagen
- Maria Natalia Rojas Velazquez
- Pediatric Endocrinology, Diabetology, and Metabolism, University Children’s Hospital
- Flemming Steen Jørgensen
- Department of Drug Design and Pharmacology, University of Copenhagen
- Amit V. Pandey
- Pediatric Endocrinology, Diabetology, and Metabolism, University Children’s Hospital
- Tomas Laursen
- Plant Biochemistry Laboratory, Department of Plant and Environmental Sciences, University of Copenhagen
- Birger Lindberg Møller
- Plant Biochemistry Laboratory, Department of Plant and Environmental Sciences, University of Copenhagen
- Nikos S. Hatzakis
- Department of Chemistry & Nanoscience Centre, University of Copenhagen
- DOI
- https://doi.org/10.1038/s41467-021-22562-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
P450 oxidoreductase (POR) selectively activates numerous cytochromes P450 (CYP), crucial for metabolism of drugs, steroids and xenobiotics and natural product biosynthesis. Here, the authors identify ligands that bind POR and bias its specificity towards CYP redox partners, activating distinct metabolic cascades in cells.
