The choice of method of introduction of active substances into the basis of the cream for the treatment of acne and demodecosis

Abstract

Among dermatological diseases demodicosis and acne occupy a very important place. The incidence of demodicosis is more than 5% and ranks seventh in frequency among dermatological diseases. It is known that demodicosis can turn into acne. Treatment of demodicosis and acne does not lose its relevance. This medical problem can be solved through the development of the composition and technology of a soft drug of complex action with the content of active substances used to treat these diseases. Since in dermatology for external use the optimal soft medicines is a cream (taking into account the medical and biological requirements for the drug for the treatment of this disease), we have developed the composition of the base, which is the rheological properties of the cream. The aim of the work is to substantiate the optimal method of introducing active pharmaceutical ingredients into the basis of a soft medicines. Materials and research methods – metronidazole, benzyl benzoate, benzoyl peroxide, emulsion base. When choosing the optimal method of introduction of active pharmaceutical ingredients to the base used pharmaco-technological research methods (homogeneity of the content of API in the base). Used a microscope with a photoresist (microscope – OLYMPUS BX-41, photoresist – OLYMPUS U-CMAD3, Japan). Active pharmaceutical ingredients was added to the base in the form of a suspension with glycerol. According to previous studies, we found that propylene glycol and polyethylene oxide were used to obtain the suspension. Studies have shown that in the process of storage for 6 months at room temperature there is a stratification of the base, in order to improve the stability of the composition of the developed cream, we introduced glycerin. Experimental studies have shown that active pharmaceutical ingredients in the form of a suspension must be introduced into the base alternately: a suspension of metronidazole, a suspension of benzoyl peroxide. After bringing the mass to homogeneity, benzyl benzoate was finally introduced. We studied 8 samples with different sequence of administration of active substances in suspension with glycerol, sample № 2 in the study showed the best results of homogeneity of the suspension, so this method we used in further studies. Experimental studies have established the procedure for the introduction of active pharmaceutical ingredients in the form of a suspension to the base: a suspension of metronidazole, a suspension of benzoyl peroxide and, last but not least, benzyl benzoate. The results of the research make it possible to develop a rational technology for the production (manufacture) of a treated soft medicines with metronidazole, benzyl benzoate and benzoyl peroxide for dermatology.

Keywords

• metronidazole
• benzyl benzoate
• benzoyl peroxide
• base