Multivariate physiological recordings in an experimental hemorrhage model
Farid Yaghouby,
Chathuri Daluwatte,
Nicole R. Marques,
Muzna Khan,
Michael Salter,
Jordan Wolf,
Christina Nelson,
John Salsbury,
Perenlei Enkhbaatar,
Michael Kinsky,
David G. Strauss,
George C. Kramer,
Christopher G. Scully
Affiliations
Farid Yaghouby
Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, United States
Chathuri Daluwatte
Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, United States
Nicole R. Marques
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, United States
Muzna Khan
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, United States
Michael Salter
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, United States
Jordan Wolf
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, United States
Christina Nelson
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, United States
John Salsbury
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, United States
Perenlei Enkhbaatar
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, United States
Michael Kinsky
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, United States
David G. Strauss
Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States
George C. Kramer
Department of Anesthesiology, The University of Texas Medical Branch, Galveston, TX, United States
Christopher G. Scully
Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, United States; Correspondence to: U.S. Food and Drug Administration, 10903 New Hampshire Ave., Building 62, Room 1129, Silver Spring, MD 20993, United States. Tel: 301-796-2928.
In this paper we describe a data set of multivariate physiological measurements recorded from conscious sheep (N = 8; 37.4 ± 1.1 kg) during hemorrhage. Hemorrhage was experimentally induced in each animal by withdrawing blood from a femoral artery at two different rates (fast: 1.25 mL/kg/min; and slow: 0.25 mL/kg/min). Data, including physiological waveforms and continuous/intermittent measurements, were transformed to digital file formats (European Data Format [EDF] for waveforms and Comma-Separated Values [CSV] for continuous and intermittent measurements) as a comprehensive data set and stored and publicly shared here (Appendix A). The data set comprises experimental information (e.g., hemorrhage rate, animal weight, event times), physiological waveforms (arterial and central venous blood pressure, electrocardiogram), time-series records of non-invasive physiological measurements (SpO2, tissue oximetry), intermittent arterial and venous blood gas analyses (e.g., hemoglobin, lactate, SaO2, SvO2) and intermittent thermodilution cardiac output measurements. A detailed explanation of the hemodynamic and pulmonary changes during hemorrhage is available in a previous publication (Scully et al., 2016) [1].
