Biopsy-Proven Lymphocytic Myocarditis With Heart Failure in a Middle-Aged Female Patient With Mixed Connective Tissue Disease

Stefano Figliozzi, MD; Stefania Rizzo, MD; Chun-Yan Cheng, MD, PhD; Sabino Iliceto, MD; Cristina Basso, MD, PhD; Alida L.P. Caforio, MD, PhD; Renzo Marcolongo, MD

JACC: Case Reports (Aug 2019)

Biopsy-Proven Lymphocytic Myocarditis With Heart Failure in a Middle-Aged Female Patient With Mixed Connective Tissue Disease

Stefano Figliozzi, MD,
Stefania Rizzo, MD,
Chun-Yan Cheng, MD, PhD,
Sabino Iliceto, MD,
Cristina Basso, MD, PhD,
Alida L.P. Caforio, MD, PhD,
Renzo Marcolongo, MD

Affiliations

Stefano Figliozzi, MD: Division of Cardiology, Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy
Stefania Rizzo, MD: Cardiovascular Pathology, Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova, Italy
Chun-Yan Cheng, MD, PhD: Division of Cardiology, Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy
Sabino Iliceto, MD: Division of Cardiology, Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy
Cristina Basso, MD, PhD: Cardiovascular Pathology, Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova, Italy
Alida L.P. Caforio, MD, PhD: Division of Cardiology, Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy; Address for correspondence: Prof. Alida L. P. Caforio, Division of Cardiology, Department of Cardiological, Thoracic, and Vascular Sciences and Public Health, Via N Giustiniani, 2, 35100 Padova, Italy.
Renzo Marcolongo, MD: Hematology and Clinical Immunology, Department of Medicine, University of Padova, Padova, Italy

Journal volume & issue: Vol. 1, no. 2
pp. 171 – 174

Abstract

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A 56-year-old woman with mixed connective tissue disease, who was on maintenance immunosuppression, developed asymptomatic left ventricular dysfunction, ventricular arrhythmia, and high troponin I. Heart catheterization showed normal coronaries and biopsy-proven, virus-negative lymphocytic myocarditis. A biopsy-guided immunosuppression upgrade effectively treated autoimmune myocarditis, which resulted in ventricular function recovery, resolution of arrhythmia, and of troponin release. (Level of Difficulty: Advanced.)

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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Abstract

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