Open Medicine
(Aug 2024)
Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
Yue Lin,
Wang Yue,
Wang Cuiying,
Niu Shu,
Dong Xihong,
Guan Yaqing,
Chen Shuchun
Affiliations
Yue Lin
Department of Endocrinology, The Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, P.R. China
Wang Yue
Department of Ultrasonography, The Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, P.R. China
Wang Cuiying
Department of Endocrinology, The Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, P.R. China
Niu Shu
Department of Endocrinology, Shijiazhuang People’s Hospital, Shijiazhuang, Hebei, 050000, P.R. China
Dong Xihong
Department of Endocrinology, The Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, P.R. China
Guan Yaqing
Department of Endocrinology, The Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, P.R. China
Chen Shuchun
Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, 050000, P.R. China
DOI
https://doi.org/10.1515/med-2024-1012
Journal volume & issue
Vol. 19,
no. 1
pp.
1581
– 6
Abstract
Read online
Empagliflozin has been shown in clinical studies to lower the risk of adverse cardiovascular events. Using proteomics, the current study aims to determine whether empagliflozin reduces aortic alterations in obese mice and to investigate its molecular mechanism of action.
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