Histopathological Pattern of Prostate Carcinoma using New Grading System in a Tertiary Centre of Saudi Arabia

Abstract

Introduction: Gleason grading of prostate carcinoma has undergone significant revisions and the new grading system has been accepted by the World Health Organisation (WHO) 2016, which is known to avoid confusion among treating urologists and the patients. Aim: To analyse the pattern of prostate carcinoma and to compare with new grading system. Materials and Methods: The present retrospective study consists of specimen obtained from transrectal ultrasound-guided core needle biopsies and transurethral resection of prostate within the duration of three years. Biopsy specimens were reviewed by histopathologists and grading of prostatic carcinoma was done according to modified Gleason grading system. Results: There were 47 cases of prostatic carcinoma in three years. The basic statistical analysis of cases and findings were applied manually. The 44 cases (94%) were adenocarcinoma and its variants. Only three cases (6%) were of small cell carcinoma, which was not assigned any grade. Conclusion: Determination of patterns especially Pattern 4 and their percentages becomes important which changes the Grade Group. The old system of Gleason Scoringisless sensitive (90.9%) and specific (95.45%) as compared to new Grade Grouping.

Keywords

• adenocarcinoma
• gleason grading
• grade group