Nature Communications (Mar 2018)
Estrogen receptor α drives pro-resilient transcription in mouse models of depression
- Zachary S. Lorsch,
- Yong-Hwee Eddie Loh,
- Immanuel Purushothaman,
- Deena M. Walker,
- Eric M. Parise,
- Marine Salery,
- Michael E. Cahill,
- Georgia E. Hodes,
- Madeline L. Pfau,
- Hope Kronman,
- Peter J. Hamilton,
- Orna Issler,
- Benoit Labonté,
- Ann E. Symonds,
- Matthew Zucker,
- Tie Yuan Zhang,
- Michael J. Meaney,
- Scott J. Russo,
- Li Shen,
- Rosemary C. Bagot,
- Eric J. Nestler
Affiliations
- Zachary S. Lorsch
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Yong-Hwee Eddie Loh
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Immanuel Purushothaman
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Deena M. Walker
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Eric M. Parise
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Marine Salery
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Michael E. Cahill
- Department of Comparative Biosciences, University of Wisconsin-Madison
- Georgia E. Hodes
- School of Neuroscience, Virginia Polytechnic Institute and State University
- Madeline L. Pfau
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Hope Kronman
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Peter J. Hamilton
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Orna Issler
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Benoit Labonté
- Department of Neuroscience and Psychiatry, Faculty of Medicine, Laval University
- Ann E. Symonds
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Matthew Zucker
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Tie Yuan Zhang
- Ludmer Centre for Neuroinformatics and Mental Health, Douglas Institute, Sackler Program for Epigenetics and Psychobiology, Departments of Psychiatry and Neurology and Neurosurgery, McGill University
- Michael J. Meaney
- Ludmer Centre for Neuroinformatics and Mental Health, Douglas Institute, Sackler Program for Epigenetics and Psychobiology, Departments of Psychiatry and Neurology and Neurosurgery, McGill University
- Scott J. Russo
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Li Shen
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Rosemary C. Bagot
- Departments of Psychology & Psychiatry, Ludmer Centre for Neuroinformatics and Mental Health, McGill University
- Eric J. Nestler
- Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-018-03567-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Stress resilience is accompanied by broad changes in gene expression. This study shows that estrogen receptor α (ERα) is a key upstream regulator of these changes in the nucleus accumbens, and that overexpression of ERα increases behavioral resilience via a sex-specific transcriptional mechanism.
