Nature Communications (Nov 2020)
Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury
- Elisa M. Floriddia,
- Tânia Lourenço,
- Shupei Zhang,
- David van Bruggen,
- Markus M. Hilscher,
- Petra Kukanja,
- João P. Gonçalves dos Santos,
- Müge Altınkök,
- Chika Yokota,
- Enric Llorens-Bobadilla,
- Sara B. Mulinyawe,
- Mário Grãos,
- Lu O. Sun,
- Jonas Frisén,
- Mats Nilsson,
- Gonçalo Castelo-Branco
Affiliations
- Elisa M. Floriddia
- Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Biomedicum
- Tânia Lourenço
- Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Biomedicum
- Shupei Zhang
- Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Biomedicum
- David van Bruggen
- Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Biomedicum
- Markus M. Hilscher
- Science for Life Laboratory, Department of Biophysics and Biochemistry, Stockholm University
- Petra Kukanja
- Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Biomedicum
- João P. Gonçalves dos Santos
- Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Biomedicum
- Müge Altınkök
- Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Biomedicum
- Chika Yokota
- Science for Life Laboratory, Department of Biophysics and Biochemistry, Stockholm University
- Enric Llorens-Bobadilla
- Department of Cell and Molecular Biology, Karolinska Institutet, Biomedicum
- Sara B. Mulinyawe
- Department of Neurobiology, Stanford University School of Medicine
- Mário Grãos
- Biocant, Technology Transfer Association
- Lu O. Sun
- Department of Neurobiology, Stanford University School of Medicine
- Jonas Frisén
- Department of Cell and Molecular Biology, Karolinska Institutet, Biomedicum
- Mats Nilsson
- Science for Life Laboratory, Department of Biophysics and Biochemistry, Stockholm University
- Gonçalo Castelo-Branco
- Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Biomedicum
- DOI
- https://doi.org/10.1038/s41467-020-19453-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
The oligodendrocyte lineage is known for its transcriptional heterogeneity, but the functional consequences of this are unclear. Here, the authors show that distinct populations of mature oligodendrocytes have spatial preferences in the brain and spinal cord and show different responses to spinal cord injury.
